The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

Table 3 CHDs in Tbx5 ^+/− trisomic and euploid mice^a

Genotype	ASD	VSD only	Overriding Aorta^b	Gerbode’s defect	AVSD^c	No defect	Total mice
Tbx5 ^+/−	11 (27.5 %)	10 (25 %)	7 (17.5 %)	4 (10 %)	2 (5 %)	13 (32.5 %)	40
Ts65Dn; Tbx5 ^+/−	12 (38.7 %)	6 (19.4 %)	18 (58.1 %)	6 (19.4 %)	6 (19.4 %)	5 (16 %)	31

^aSeveral animals had more than one defect. (see Additional file 1: Table S1)
^bThere is a significant difference between euploid and trisomic Tbx5 heterozygous mice in the occurrence of overriding aorta (p = 0.0004)
^cThe difference between euploid and trisomic Tbx5 heterozygous mice in AVSD is approaching significance (p = 0.07)

ISSN: 1471-213X