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  1. Real-time quantitative polymerase chain reaction (RT-qPCR) is a widely-used standard assay for assessing gene expression. RT-qPCR data requires reference genes for normalization to make the results comparable....

    Authors: Jie Ren, Ningning Zhang, Xiangjie Li, Xiaogang Sun and Jiangping Song

    Citation: BMC Developmental Biology 2021 21:13

    Content type: Research article

    Published on:

  2. The miR-200 family of microRNAs plays a significant role in inhibiting mammary tumor growth and progression, and its members are being investigated as therapeutic targets. Additionally, if future studies can p...

    Authors: Majesta J. Roth and Roger A. Moorehead

    Citation: BMC Developmental Biology 2021 21:12

    Content type: Review

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  3. Flying is an essential function for mosquitoes, required for mating and, in the case of females, to get a blood meal and consequently function as a vector. Flight depends on the action of the indirect flight m...

    Authors: Antonio Celestino-Montes, Salvador Hernández-Martínez, Mario Henry Rodríguez, Febe Elena Cázares-Raga, Carlos Vázquez-Calzada, Anel Lagunes-Guillén, Bibiana Chávez-Munguía, José Ángel Rubio-Miranda, Felipe de Jesús Hernández-Cázares, Leticia Cortés-Martínez and Fidel de la Cruz Hernández-Hernández

    Citation: BMC Developmental Biology 2021 21:11

    Content type: Research article

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  4. Mice with a loss of function mutation in Wdpcp were described previously to display severe birth defects in the developing heart, neural tube, and limb buds. Further characterization of the skeletal phenotype of

    Authors: Mark T. Langhans, Jingtao Gao, Ying Tang, Bing Wang, Peter Alexander and Rocky S. Tuan

    Citation: BMC Developmental Biology 2021 21:10

    Content type: Research

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  5. Yaks have a strong adaptability to the plateau environment, which can be attributed to the effective oxygen utilization rate of their lung tissue. Elastic fibre confers an important adaptive structure to the a...

    Authors: Jingyi Li, Xiangqiong Meng, Lihan Wang, Yang Yu, Hongxian Yu and Qing Wei

    Citation: BMC Developmental Biology 2021 21:9

    Content type: Research article

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  6. Vasculogenesis in amniotes is often viewed as two spatially and temporally distinct processes, occurring in the yolk sac and in the embryo. However, the spatial origins of the cells that form the primary intra...

    Authors: C. Collart, A. Ciccarelli, K. Ivanovitch, I. Rosewell, S. Kumar, G. Kelly, A. Edwards and J. C. Smith

    Citation: BMC Developmental Biology 2021 21:8

    Content type: Research

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  7. Heparan sulfate proteoglycan 2 (HSPG2) encodes for perlecan, a large proteoglycan that plays an important role in cartilage formation, cell adhesion, and basement membrane stability. Mutations in HSPG2 have been ...

    Authors: Barbara S. Castellanos, Nayeli G. Reyes-Nava and Anita M. Quintana

    Citation: BMC Developmental Biology 2021 21:7

    Content type: Research article

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  8. Cardiomyocytes proliferate rapidly during fetal life but lose their ability of proliferation soon after birth. However, before terminal withdrawal from the cell cycle, cardiomyocytes undergo another round of c...

    Authors: Mir Ali, Daniela Liccardo, Tongtong Cao and Ying Tian

    Citation: BMC Developmental Biology 2021 21:6

    Content type: Research article

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  10. Our previous study have shown that the PSMD11 protein was an important survival factor for cancer cells except for its key role in regulation of assembly and activity of the 26S proteasome. To further investig...

    Authors: Linlin Zhao, Jinming Zhao, Yingying Zhang, Lele Wang, Longyan Zuo, Airu Niu, Wei Zhang, Xia Xue, Suhong Zhao, Chao Sun, Kailin Li, Jue Wang, Zhimin Bian, Xiaogang Zhao, Dieter Saur, Barbara Seidler…

    Citation: BMC Developmental Biology 2021 21:4

    Content type: Methodology article

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  12. Mammalian early development comprises the proliferation, differentiation, and self-assembly of the embryonic cells. The classic experiment undertaken by Townes and Holtfreter demonstrated the ability of dissoc...

    Authors: Jeffrey D. Tse, Robert Moore, Yue Meng, Wensi Tao, Elizabeth R. Smith and Xiang-Xi Xu

    Citation: BMC Developmental Biology 2021 21:2

    Content type: Research article

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  13. Phosphate is the major ingredient of bone tissue, and is also an important component of commercial bone substitute materials, bone scaffolds, and implant surface coatings. With the dissolution of the bone subs...

    Authors: Hengzhang Lin, Yong Zhou, Qun Lei, Dong Lin, Jiang Chen and Chuhuo Wu

    Citation: BMC Developmental Biology 2021 21:1

    Content type: Research article

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  14. Joubert syndrome and related disorders (JSRD) and Jeune syndrome are multisystem ciliopathy disorders with overlapping phenotypes. There are a growing number of genetic causes for these rare syndromes, includi...

    Authors: L. Powell, M. Barroso-Gil, G. J. Clowry, L. A. Devlin, E. Molinari, S. A. Ramsbottom, C. G. Miles and J. A. Sayer

    Citation: BMC Developmental Biology 2020 20:26

    Content type: Research article

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  15. Genotype independent transformation and whole plant regeneration through somatic embryogenesis relies heavily on the intrinsic ability of a genotype to regenerate. The critical genetic architecture of non-embr...

    Authors: Li Wen, Wei Li, Stephen Parris, Matthew West, John Lawson, Michael Smathers, Zhigang Li, Don Jones, Shuangxia Jin and Christopher A. Saski

    Citation: BMC Developmental Biology 2020 20:25

    Content type: Research article

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  17. Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there ...

    Authors: Susanne Vogeler, Stefano Carboni, Xiaoxu Li, Nancy Nevejan, Sean J. Monaghan, Jacqueline H. Ireland and Alyssa Joyce

    Citation: BMC Developmental Biology 2020 20:23

    Content type: Research article

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  18. Tissue regeneration mediated by mesenchymal stem cells (MSCs) is deemed a desirable way to repair teeth and craniomaxillofacial tissue defects. Nevertheless, the molecular mechanisms about cell proliferation a...

    Authors: Xiaomin Su, Haoqing Yang, Ruitang Shi, Chen Zhang, Huina Liu, Zhipeng Fan and Jianpeng Zhang

    Citation: BMC Developmental Biology 2020 20:22

    Content type: Research article

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  19. Organismal fitness can be determined at early life-stages, but phenotypic variation at early life-stages is rarely considered in studies on evolutionary diversification. The trophic apparatus has been shown to...

    Authors: Samantha V. Beck, Katja Räsänen, Camille A. Leblanc, Skúli Skúlason, Zophonías O. Jónsson and Bjarni K. Kristjánsson

    Citation: BMC Developmental Biology 2020 20:21

    Content type: Research article

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  20. Monocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role in regulating the development of Leydig cells via autocrine and paracri...

    Authors: Xiangcheng Zhan, Jingwei Zhang, Saiyang Li, Xiaolu Zhang, Linchao Li, Tiantian Song, Qunlong Liu, Jun Lu, Yunfei Xu and Ren-Shan Ge

    Citation: BMC Developmental Biology 2020 20:20

    Content type: Research article

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  21. Masculinizer (Masc) plays a pivotal role in male sex determination in the silkworm, Bombyx mori. Masc is required for male-specific splicing of B. mori doublesex (Bmdsx) transcripts. The male isoform of Bmdsx (Bm...

    Authors: Tomohisa Yuzawa, Misato Matsuoka, Megumi Sumitani, Fugaku Aoki, Hideki Sezutsu and Masataka G. Suzuki

    Citation: BMC Developmental Biology 2020 20:19

    Content type: Research article

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  22. The morphogenesis of the shell field is an essential step of molluscan shell formation, which exhibits both conserved features and interlineage variations. As one major gastropod lineage, the patellogastropods...

    Authors: Weihong Yang, Pin Huan and Baozhong Liu

    Citation: BMC Developmental Biology 2020 20:18

    Content type: Research article

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  23. p120 catenin (p120ctn) is an important component in the cadherin-catenin cell adhesion complex because it stabilizes cadherin-mediated intercellular junctions. Outside these junctions, p120ctn is actively invo...

    Authors: Tim Pieters, Ellen Sanders, Huiyu Tian, Jolanda van Hengel and Frans van Roy

    Citation: BMC Developmental Biology 2020 20:17

    Content type: Research article

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  25. Changes in transcellular bioelectrical patterns are known to play important roles during developmental and regenerative processes. The Drosophila follicular epithelium has proven to be an appropriate model system...

    Authors: Susanne Katharina Schotthöfer and Johannes Bohrmann

    Citation: BMC Developmental Biology 2020 20:15

    Content type: Research article

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  26. Hazels (Corylus spp.) are economically important nut-producing species in which ovule development determines seed plumpness, one of the key parameters reflecting nut quality. microRNAs (miRNAs) play important rol...

    Authors: Jianfeng Liu, Qizheng Luo, Xingzheng Zhang, Qiang Zhang and Yunqing Cheng

    Citation: BMC Developmental Biology 2020 20:13

    Content type: Research article

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  27. Archipelago (Ago) is a Drosophila homolog of mammalian F-box and WD repeat domain-containing 7 (FBW7, also known as FBXW7). In previous studies, FBW7 has been addressed as a tumor suppressor mediating ubiquitin-d...

    Authors: Sujin Nam and Kyung-Ok Cho

    Citation: BMC Developmental Biology 2020 20:14

    Content type: Research article

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  28. Scaffold proteins support a variety of key processes during animal development. Mutant mouse for the MAGUK protein Discs large 5 (Dlg5) presents a general growth impairment and moderate morphogenetic defects.

    Authors: Parvathy Venugopal, Hugo Veyssière, Jean-Louis Couderc, Graziella Richard, Caroline Vachias and Vincent Mirouse

    Citation: BMC Developmental Biology 2020 20:10

    Content type: Research article

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  29. Mammalian early embryo development requires a well-orchestrated interplay of cell signaling pathways. Notch is a major regulatory pathway involved in cell-fate determination in embryonic and adult scenarios. H...

    Authors: Mariana R. Batista, Patrícia Diniz, Ana Torres, Daniel Murta, Luís Lopes-da-Costa and Elisabete Silva

    Citation: BMC Developmental Biology 2020 20:9

    Content type: Research article

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  30. During mammalian cerebral cortex development, different types of projection neurons are produced in a precise temporal order and in stereotypical numbers. The mechanisms regulating timely generation of neocort...

    Authors: Anthony Kischel, Christophe Audouard, Mohamad-Ali Fawal and Alice Davy

    Citation: BMC Developmental Biology 2020 20:12

    Content type: Research article

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  31. The tissue regeneration process requires high oxygen and energy levels. Cytoglobin (Cygb) is a member of the globin family, which has the ability to bind oxygen, plays a role in dealing with oxidative stress, ...

    Authors: Titta Novianti, Vetnizah Juniantito, Ahmad Aulia Jusuf, Evy Ayu Arida, Mohamad Sadikin and Sri Widia A. Jusman

    Citation: BMC Developmental Biology 2020 20:11

    Content type: Research article

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  32. Hair follicles are an appendage of the vertebrate epithelium in the skin that arise from the embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) are the key dermal compon...

    Authors: Gongyan Liu, Shu Li, Hongli Liu, Yanli Zhu, Liya Bai, Haitao Sun, Shuxia Gao, Wenxue Jiang and Fuchang Li

    Citation: BMC Developmental Biology 2020 20:8

    Content type: Research article

    Published on:

  33. Octopus vulgaris has been an iconic cephalopod species for neurobiology research as well as for cephalopod aquaculture. It is one of the most intelligent and well-studied invertebrates, possessing both long- and ...

    Authors: Astrid Deryckere, Ruth Styfhals, Erica A. G. Vidal, Eduardo Almansa and Eve Seuntjens

    Citation: BMC Developmental Biology 2020 20:7

    Content type: Research article

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  34. Eyespot color pattern formation on butterfly wings is sensitive to physical damage and physical distortion as well as physical contact with materials on the surface of wing epithelial tissue at the pupal stage...

    Authors: Joji M. Otaki

    Citation: BMC Developmental Biology 2020 20:6

    Content type: Research article

    Published on:

  35. Bioelectrical signals are known to be involved in the generation of cell and tissue polarity as well as in cytoskeletal dynamics. The epithelium of Drosophila ovarian follicles is a suitable model system for stud...

    Authors: Susanne Katharina Schotthöfer and Johannes Bohrmann

    Citation: BMC Developmental Biology 2020 20:5

    Content type: Research article

    Published on:

  36. Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previo...

    Authors: Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy and Meritxell Huch

    Citation: BMC Developmental Biology 2020 20:4

    Content type: Methodology article

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  39. In normal mammalian development a high percentage of implantations is lost by spontaneous resorption. This is a major problem in assisted reproduction and blastocyst transfer. Which embryo will be resorbed is ...

    Authors: Barbara Drews, Luis Flores Landaverde, Anja Kühl and Ulrich Drews

    Citation: BMC Developmental Biology 2020 20:1

    Content type: Research article

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  40. Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development...

    Authors: Haijun Zhang, Yu Gao, Peipei Qian, Zhangji Dong, Wenjin Hao, Dong Liu and Xuchu Duan

    Citation: BMC Developmental Biology 2019 19:25

    Content type: Research article

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  41. Tardigrades are microscopic organisms, famous for their tolerance against extreme environments. The establishment of rearing systems of multiple species has allowed for comparison of tardigrade physiology, in ...

    Authors: Yuki Yoshida, Kenta Sugiura, Masaru Tomita, Midori Matsumoto and Kazuharu Arakawa

    Citation: BMC Developmental Biology 2019 19:24

    Content type: Research article

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  42. Epigenetic regulation of oocyte-specific maternal factors is essential for oocyte and early embryonic development. KPNA7 is an oocyte-specific maternal factor, which controls transportation of nuclear proteins...

    Authors: Lei Wang, Jacqelyn M. Hand, Liyuan Fu, George W. Smith and Jianbo Yao

    Citation: BMC Developmental Biology 2019 19:23

    Content type: Research article

    Published on:

  43. During Drosophila oogenesis, the follicular epithelium differentiates into several morphologically distinct follicle-cell populations. Characteristic bioelectrical properties make this tissue a suitable model sys...

    Authors: Isabel Weiß and Johannes Bohrmann

    Citation: BMC Developmental Biology 2019 19:22

    Content type: Research article

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  44. Animals with polyploid, hybrid nuclei offer a challenge for models of gene expression and regulation during embryogenesis. To understand how such organisms proceed through development, we examined the timing a...

    Authors: Noah D. Charney, Jacob E. Kubel, Craig T. Woodard, Blanca I. Carbajal-González, Samantha Avis, Julia A. Blyth, Charles S. Eiseman, John Castorino and John H. Malone

    Citation: BMC Developmental Biology 2019 19:21

    Content type: Research article

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  45. Immature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1). Release from this meiotic arrest and germinal vesicle breakdown is de...

    Authors: Alaa A. Eisa, Santanu De, Ariana Detwiler, Eva Gilker, Alexander C. Ignatious, Srinivasan Vijayaraghavan and Douglas Kline

    Citation: BMC Developmental Biology 2019 19:20

    Content type: Research article

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  46. Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to...

    Authors: Shweta Varshney, Hua-Xing Wei, Frank Batista, Mohd Nauman, Subha Sundaram, Katherine Siminovitch, Ankit Tanwar and Pamela Stanley

    Citation: BMC Developmental Biology 2019 19:19

    Content type: Research article

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  47. Sonic hedgehog (Shh) is an important signalling protein involved in the induction of early cartilaginous differentiation. Herein, we demonstrate that Shh markedly induces chondrogenesis of rabbit bone marrow s...

    Authors: Liyang Chen, Gejun Liu, Wenjun Li and Xing Wu

    Citation: BMC Developmental Biology 2019 19:18

    Content type: Research article

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  49. The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical rol...

    Authors: Michael Reimer Jr, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan and Sridhar Rao

    Citation: BMC Developmental Biology 2019 19:16

    Content type: Research article

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  50. Insulin/insulin-like growth peptide signaling (IIS) down-regulates hemolymph sugar level and facilitates larval growth in the soybean pod borer, Maruca vitrata. The objective of this study is to determine whether...

    Authors: Md. Abdullah Al Baki, Dae-Weon Lee, Jin Kyo Jung and Yonggyun Kim

    Citation: BMC Developmental Biology 2019 19:14

    Content type: Research article

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